Patrick J Sinko Selected Research

Camptothecin

1/2014	Selective cytotoxicity and combined effects of camptothecin or paclitaxel with sodium-R-alpha lipoate on A549 human non-small cell lung cancer cells.
2/2010	A series of alpha-amino acid ester prodrugs of camptothecin: in vitro hydrolysis and A549 human lung carcinoma cell cytotoxicity.
1/2010	Pulmonary targeting microparticulate camptothecin delivery system: anticancer evaluation in a rat orthotopic lung cancer model.
8/2007	Exploitation of drug-induced Bcl-2 overexpression for restoring normal apoptosis function: a promising new approach to the treatment of multidrug resistant cancer.
8/2005	Tumor-targeted and activated bioconjugates for improved camptothecin delivery.
11/2004	Tumor-targeted bioconjugate based delivery of camptothecin: design, synthesis and in vitro evaluation.
8/2002	Enhancing the anticancer efficacy of camptothecin using biotinylated poly(ethylene glycol) conjugates in sensitive and multidrug-resistant human ovarian carcinoma cells.

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Patrick J Sinko Research Topics

Disease

15	Neoplasms (Cancer) 01/2022 - 08/2002
11	Inflammation (Inflammations) 05/2021 - 06/2010
8	Edema (Dropsy) 01/2023 - 10/2010
6	Wounds and Injuries (Trauma) 03/2024 - 02/2010
4	Noninfiltrating Intraductal Carcinoma (DCIS) 01/2022 - 01/2018
4	Neoplasm Metastasis (Metastasis) 01/2016 - 01/2014
4	Breast Neoplasms (Breast Cancer) 01/2015 - 05/2004
3	Bacterial Vaginosis 05/2014 - 03/2011
2	HIV Infections (HIV Infection) 12/2015 - 01/2004
2	Infections 12/2015 - 03/2013
2	Tuberculosis (Tuberculoses) 05/2015 - 05/2013
2	Hyperplasia 10/2014 - 10/2011
2	Lung Injury 12/2012 - 02/2011
2	Carcinoma (Carcinomatosis) 02/2010 - 08/2002
2	Leukemia 08/2007 - 10/2006
1	Burns 01/2023
1	Corneal Injuries 10/2022
1	Inborn Genetic Diseases (Disease, Hereditary) 04/2016
1	Colorectal Neoplasms (Colorectal Cancer) 01/2016
1	Colonic Neoplasms (Colon Cancer) 03/2015
1	Blister (Bulla) 10/2014
1	Follicular Cyst (Follicular Cysts) 06/2014
1	Circulating Neoplastic Cells 01/2014
1	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 01/2014
1	Pulmonary Fibrosis (Fibrosing Alveolitis) 12/2012
1	Fibrosis (Cirrhosis) 12/2012
1	Parakeratosis 10/2011
1	Poisoning 02/2011
1	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 02/2011
1	Bronchiolitis Obliterans 02/2011
1	Bronchitis 02/2011

Drug/Important Bio-Agent (IBA)

9	Mustard Gas (Sulfur Mustard)IBA 10/2022 - 06/2010
7	Proteins (Proteins, Gene)FDA Link 01/2015 - 05/2004
7	CamptothecinIBA 01/2014 - 08/2002
6	Irritants (Vesicants)IBA 01/2023 - 02/2010
6	HydrogelsIBA 05/2014 - 05/2006
5	2- cyclohexylidenhydrazo- 4- phenyl- thiazoleIBA 01/2010 - 08/2002
4	ProdrugsIBA 01/2022 - 01/2008
4	Ethylene Glycol (Monoethylene Glycol)IBA 09/2018 - 08/2002
4	Bacillus subtilis sboA proteinIBA 05/2014 - 03/2011
3	Mechlorethamine (Nitrogen Mustard)FDA Link 03/2024 - 12/2012
3	EnzymesIBA 05/2021 - 01/2008
3	Dendrimers (Dendrons)IBA 03/2015 - 01/2014
3	Alkylating AgentsIBA 10/2014 - 10/2011
2	Ciclopirox (Loprox)FDA LinkGeneric 01/2022 - 10/2020
2	PolymersIBA 09/2018 - 01/2012
2	Doxorubicin (Adriamycin)FDA LinkGeneric 09/2018 - 01/2018
2	Mifepristone (RU 486)FDA Link 01/2016 - 01/2015
2	Epithelial Cell Adhesion MoleculeIBA 01/2016 - 02/2015
2	Biomarkers (Surrogate Marker)IBA 03/2015 - 02/2011
2	AntibodiesIBA 03/2015 - 02/2015
2	Antimicrobial PeptidesIBA 04/2012 - 03/2011
2	AcidsIBA 03/2011 - 01/2003
2	Peptides (Polypeptides)IBA 03/2011 - 01/2003
2	Doxycycline (Periostat)FDA LinkGeneric 02/2011 - 02/2010
2	Folic Acid (Vitamin M)FDA LinkGeneric 08/2005 - 11/2004
1	AcetoneIBA 01/2023
1	SolventsIBA 01/2023
1	Indicators and Reagents (Reagents)IBA 01/2023
1	Dichlorodiphenyldichloroethane (DDD)IBA 01/2023
1	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 05/2021
1	AntioxidantsIBA 05/2021
1	CatalaseIBA 05/2021
1	MetalsIBA 10/2020
1	Therapeutic UsesIBA 01/2018
1	DNA (Deoxyribonucleic Acid)IBA 04/2016
1	E-SelectinIBA 01/2016
1	Intercellular Adhesion Molecule-1 (Intercellular Adhesion Molecule 1)IBA 01/2016
1	Monoclonal AntibodiesIBA 01/2016
1	Silicon Dioxide (Silica)FDA LinkGeneric 01/2016
1	Anti-HIV Agents (AIDS Drugs)IBA 12/2015
1	Isoniazid (Ftivazide)FDA LinkGeneric 05/2015
1	Sialyl Lewis X AntigenIBA 03/2015
1	Differentiation AntigensIBA 10/2014
1	Laminin (Merosin)IBA 10/2014
1	Sulfides (Thioethers)IBA 10/2014
1	Keratin-10IBA 10/2014
1	Keratin-6 (Keratin 6A)IBA 10/2014
1	Galectin 3 (LGALS3)IBA 06/2014
1	Polyethylene Glycols (Polyethylene Glycol)FDA LinkGeneric 05/2014
1	SodiumIBA 01/2014
1	Paclitaxel (Taxol)FDA LinkGeneric 01/2014
1	FibrinIBA 12/2012
1	Nitric Oxide (Nitrogen Monoxide)FDA Link 12/2012
1	Nitric Oxide Synthase (NO Synthase)IBA 12/2012
1	monolaurinIBA 04/2012
1	N(alpha)-lauroylarginine ethyl esterIBA 04/2012
1	Lysine (L-Lysine)FDA Link 04/2012
1	Proliferating Cell Nuclear Antigen (PCNA)IBA 10/2011
1	Cyclooxygenase 2 (Cyclooxygenase-2)IBA 10/2011
1	Caspase 3 (Caspase-3)IBA 10/2011
1	CaspasesIBA 02/2011
1	DNA Repair EnzymesIBA 02/2011
1	DisulfidesIBA 02/2011

Therapy/Procedure

6	Therapeutics 05/2021 - 01/2008
3	Drug Therapy (Chemotherapy) 01/2023 - 08/2007
2	Chemoprevention 01/2016 - 01/2015
1	Radiotherapy 01/2022
1	Highly Active Antiretroviral Therapy (HAART) 12/2015
1	Art Therapy 12/2015